| Serum osteoprotegerin and fetuin-A level is associated with coronary artery calcification score in the patients with end-stage renal disease |
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Sang Wook Kim, Hae Hyuk Jung, Heon Han |
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고려대학교 의과대학 내과학교실 |
| 원저 : 혈액투석 중인 말기 신부전증 환자에서 관상동맥혈관 석회화와 혈청 Osteoprotegerin 및 Fetuin-A 농도의 상관관계 |
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김상욱, Hae Hyuk Jung, Heon Han |
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| Abstract |
Background : Coronary artery calcification is frequently seen in hemodialysis patients. The development and progression of coronary artery calcification is similar to osteogenesis, and a naturally occurring serum inhibitor of calcification may be involved.
The aim of this study was to evaluate the relationship between coronary artery calcification, bone remodeling related factor, serum osteoprotegerin (OPG), calcification inhibitor and the serum fetuin-A levels in hemodialysis patients.
Methods
: A total of 51 hemodialysis patient were assessed for their coronary artery calcium (CAC) scores with using multirow spiral computed tomography and measuring the serum OPG level, the serum fetuin-A level, the biochemical markers of inflammation, the lipid profile and the mineral metabolism.
Results
: The mean serum OPG level was 3,561¡¾1,160 pg/mL and the mean serum fetuin-A level was 28.5¡¾ 4.1 mg/dL.
The CAC scores were significantly correlated with the duration of dialysis (p=0.0225), hs-CRP (p=0.0392), serum phosphate (p=0.0341), Ca x P (p=0.0434), the serum OPG level (p=0.0026) and LDL-cholesterol (p=0.0438), after adjusting for age, gender, BMI, smoking history and the presence of diabetes. Multiple regression analysis showed that the CAC scores were significantly associated with the serum OPG level (p<0.0001) and the serum phosphate level (p=0.0003). The subgroup of the patients with a CAC score greater than 400 (the severe CAC group) had significantly higher OPG levels and lower fetuin-A levels than the groups of the patients with lower CAC scores.
Conclusions
: Our data suggest that the CAC scores in the patients undergoing hemodialysis were related with higher serum OPG and higher serum phosphate levels. The serum fetuin-A level was significantly lower in the patients with severe coronary artery calcification.(Korean J Med 72:451-458, 2007)
Key Words : Coronary disease, Calcification, Osteoprotegerin, Fetuin-A |
| Key Words:
Coronary disease, Calcification, Osteoprotegerin, Fetuin-A |
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