| Serum gamma-glutamyl transferase activity has no prognostic value in patients with acute myocardial infarction |
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Jang Hoon Lee, Shung Chull Chae, Hyun Sang Lee, Yongwhi Park, Hyeon Min Ryu, Soon Hak Lee, Myung Hwan Bae, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Jae Eun Jun, Wee Hyun Park |
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고려대학교 의과대학 내과학교실 |
| 원저 : 급성 심근경색 환자에서 예후 예측인자로 혈청 감마-글루타밀 트랜스퍼라제가 유용한가? |
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이장훈, Shung Chull Chae, Hyun Sang Lee, Yongwhi Park, Hyeon Min Ryu, Soon Hak Lee, Myung Hwan Bae, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Jae Eun Jun, Wee Hyun Park |
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| Abstract |
Background : Serum gamma-glutamyl transferase activity (GGT) is able to catalyse low-density lipoprotein oxidation in coronary atherosclerotic plaques and has a role in the pathogenesis of atherosclerosis. GGT has been shown to be an independent risk factor for cardiac mortality in patients with a previous myocardial infarction. The purpose of this study is to determine the prognostic value of GGT within its normal range at an acute stage in patients with acute myocardial infarction.
Methods
: In a retrospective study, GGT and other cardiac risk factors were evaluated in 192 patients (M/F=143/49; mean age: 60.8¡¾11.8 years) who were diagnosed with an acute myocardial infarction at the emergency room. We compared the serum GGT values for each patient with or without a cardiac event, including cardiac death, non-fetal myocardial infarction and unstable angina, after an acute myocardial infarction for a mean follow-up of 16.5¡¾10.8
months.
Results
: During the follow-up period, 17 patients underwent cardiac death and experienced an acute myocardial infarction and 23 patients had unstable angina. Although the mean GGT values were significantly different from patients with cardiac events (29.5¡¾10.0 U/L vs 25.0¡¾11.2 U/L, p=0.024), serum GGT was not an independent cardiac risk factor for a cardiac event based on multivariate analysis adjusted for age, sex, alcohol and known cardiovascular risk factors.
Conclusions
: Serum GGT within its normal range at an acute stage in patients that experienced an acute myocardial infarction is not an independent prognostic marker.(Korean J Med 72:281-289, 2007)
Key Words : Gamma-glutamyl transferase, Risk factors, Acute myocardial infarction
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| Key Words:
Gamma-glutamyl transferase, Risk factors, Acute myocardial infarction |
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