| A randomized controlled trial assessing Korea red ginseng treatment of Helicobacter pylori-associated chronic gastritis |
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Deog Ki Kim, Jeong A Lee, Young Bae Kim, Kee Myung Lee, Ki Baik Hahm |
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고려대학교 의과대학 내과학교실 |
| 원저: Helicobacter pylori 연관 만성 위염 환자에서 고려홍삼 치료의 효능에 대한 무작위 연구 |
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김덕기, Jeong A Lee, Young Bae Kim, Kee Myung Lee, Ki Baik Hahm |
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| Abstract |
Background : As Korea red ginseng has been reported to show a significant protective effect against H. pylori-induced cytotoxicity and DNA damage in vitro, we designed a study to assess the
efficacy of red ginseng treatment in patients with H. pylori associated chronic gastritis.
Methods
: A total of 84 patients with H. pylori-associated chronic gastritis were recruited and randomly divided into two groups. During the trial, 34 patients out of 42 patients in the placebo control group and 36 patients out of 42 patients in the red ginseng group completed the protocol. The patients received a one week triple therapy for the eradication of H. pylori and then received either
placebo capsules that were composed of flour for the placebo group or red ginseng capsules for the treatment group, which were administered for 10 weeks. An endoscopic examination of gastritis with a visual analogue scale, a test for detection of H. pylori, immunohistochemistry of 8-OHdG, the 8-OHdG immunohistochemical staining for assessing oxidative DNA damage and TUNEL staining
for apoptosis were performed, respectively.
Results
: H. pylori eradication rates were augmented in the red ginseng group as compared to the placebo group (91.7% in the red ginseng group and 79.4% in the placebo group), but there was
no statistical significance (p=0.147). For an analysis of gastritis based on Updated Sydney System, the red ginseng group showed significant improvement in neutrophil infiltrations (p=0.008) and
intestinal metaplasia (p=0.005). An attenuation of 8-OHdG immunohistostaining after treatment was seen more frequently in the red ginseng group (p<0.001). An attenuation of DNA damage and
apoptosis was seen for the red ginseng group as compared to the placebo group (p<0.001).
Conclusions
: Supplementary administration of red ginseng augmented eradication rates of H. pylori, attenuated gastric inflammation, and reduced oxidative DNA damage and apoptosis,
suggesting the clinical usefulness of red ginseng.(Korean J Med 72:20-28, 2007)
Key Words : Red ginseng, Helicobacter pylori, Chronic gastritis
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| Key Words:
Red ginseng, Helicobacter pylori, Chronic gastritis |
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