| A case of propylthiouracil-resistant Graves’ disease |
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계명대학교 의과대학 내과학교실 |
| 증례 : Propylthiouracil 치료에 내성을 보인 그레이브스병 1예 |
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이유민&#;노혜정&#;임윤혁&#;박병현&#;조정구, , , , |
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Department of Internal Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea |
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| Abstract |
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Graves' disease is an autoimmune disease characterized by diffuse hyperplasia and hypersecretion of the thyroid gland, infiltrative ophthalmopathy and localized myxedema. Antithyroid drugs have been a mainstay of treatment Graves' disease. Propylthiouracil (PTU) has been used for hyperthyroidism and it has an effective reaction in most cases. In the general use of PTU for hyperthyroidism, any resistance or negative reaction to the medication is rare and several possible mechanisms for this have been considered. The first is that patients with more severe disease and larger thyroid gland respond to antithyroid agents more slowly. The second is the malabsorption of drugs from the gastointestinal system. The third is the rapid turnover or metabolism of antithyroid drug within the thyroid itself. Finally, the compliance of patients must be questioned in any patients who fail to respond to medication. We experienced a case of PTU-resistant Graves' disease and report this case with review of the literature.(Korean J Med 71:S1035-S1038, 2006) |
| Key Words:
Graves' disease, PTU resistant |
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