| Protective effects of mastic in non-steroidal anti-inflammatory drug induced gut damage and bacterial translocation in a rat model |
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Chae Heo, Suk Won Kim, Kwang Jin Kim, Dae Won Kim, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang |
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고려대학교 의과대학 내과학교실 |
| 원저:백서에서 비스테로이드성 항염제에 의한 장관 손상과 장내세균전위에 대한 마스틱의 예방효과 |
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허 채, Suk Won Kim, Kwang Jin Kim, Dae Won Kim, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang |
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| Abstract |
Background : NSAIDs induce gut damage and bacterial translocation throughout the entire
gastrointestinal tract. The aim of the present study was to examine whether mastic, a natural
resinous exudate obtained from the Pistacia lentiscus treetrees, can reduce diclofenac induce gut
damage and bacterial translocation in rats.
Methods
: 32 SD rats were divided into four groups; a control group, diclofenac group, diclofenac
with 0.3 cc/kg mastic group and diclofenac with 1.0 cc/kg mastic group. Mastic oils were
administered 3 hours before diclofenac administration (100 mg/kg orally ¡¿2 days). Intestinal
permeability, enteric aerobic bacterial counts in the distal ileum and cecum, intestinal adhesion, lipid
peroxidation of distal ileum, and bacterial translocation to mesenteric lymph nodes, liver, spleen,
kidney and heart were measured, respectively
Results
: Diclofenac caused marked increase in intestinal permeability, enteric bacterial numbers
in distal ileum and cecum, intestinal adhesion, lipid peroxidation of the distal ileum, and bacterial
translocation to mesenteric lymph nodes, liver, spleen, kidney and heart of which event were reduced
with Mostic coadminist. Howere mastic oil showed significant profect effects in 1.0 cc/kg dose.
Conclusions
: Mastic was proven to have beneficial effects on preventing NSAID induced gut
injury and bacterial translocation in a rat model.(Korean J Med 71:354-361, 2006)
Key Words : Anti-Inflammatory Agents, Non-Steroidal, Adverse effects, Intestine, Bacterial
translocation, Mastic |
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