|
|
Hyun Choon Shin, Im Il Na, Tak Yun, Keun Wook Lee, Eun Gee Song, In Sil Choi, Do Youn Oh, Jee Hyun Kim, Jong Seok Lee, Sung Soo Yoon, Seon Yang Park, B |
|
Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea |
| 원저 : 60세 이상의 급성 골수성 백혈병 115명에 대한 후향적 분석 (Original Articles : Acute myelogenous Leukemia in the elderly (≥60): retrospective study of 115 patients) |
|
신현춘, 나임일, 윤탁, 이근욱, 송은기, 최인실, 오도연, 김지현, 이종석, 윤성수, 박선양, 김병국 |
|
|
|
|
|
|
| Abstract |
Background : Acute myelogenous leukemia (AML) is frequently encountered in elderly patients
whereas intensive chemotherapy yield lower rate of complete remission (CR) and survival than young
patients. This study was aimed to review the clinical features and treatment outcomes of elderly
patients (≥60) with AML.
Methods
: We respectively reviewed the clinical features, laboratory findings and outcomes of
treatment from the medical records of 115 patients with the elderly AML (≥60), admitted in Seoul
National University Hospital, between Jan.1995 and Dec.2004
Results
: Their median age was 66 (60～86) years with male predominance (M:F=68:47).
Complete response rate in patients with conventional chemotherapy was 66.7% (42 of 63 patients;
95% CI 50.2～78.4). Median overall survival (OS) was 5.2 months with clinical benefit in the
conventional chemotherapy group, compared to supportive or palliative group (11.5 vs 0.9months;
p<0.0001). In between two age groups, the sixties (n=69) showed higher CR rate (69.0 vs 61.9%;
p=0.9) and longer median overall survival (7.0 vs 4.4months; p=0.8) than patients group of the
seventies (n=38) but without statistical significance.
Conclusions
: Conventional induction chemotherapy improved survival rate than palliative or
supportive treatment.(Korean J Med 70:196-206, 2006)
Key Words : Acute myelogenous leukemia, Elderly, Prognosis |
| Key Words:
Acute myelogenous leukemia, Elderly, Prognosis |
|
PDF Links
Full text via DOI
Download Citation
