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Jae Phil Choi, Kwan Sik Lee, Yong Jae Lee, Choong Hyun Lee |
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이화여자대학교 의과대학 내과학교실, 의과학연구소, 병리학교실* |
| 원저 : 한센병 병력자들의 C형간염: 유전자형 및 위험요인 연구 (Original Articles : Hepatitis C in Leprous patients: Genotype and risk factor study) |
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최재필, 이관식, 이용제, 이충현 |
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| Abstract |
Background : On previous reports, the incidence of hepatitis C in Korean leprous patients is too high (55.6～69%). We investigated the percentage of the leprous patients with hepatitis C, genotypes,
and risk factors in National Sorokdo Hospital.
Methods
: Out of total 714 leprous patients in National Sorokdo Hospital, 147 selected risky patients (with abnormal AST/ALT, platelet≤150,000/mm3, known hepatitis C) were tested for hepatitis C antibody (Radioimmunoassay) and finally 45 HCV antibody positive-patients were tested for HCV RT-PCR and genotypes.
Results
: The percentage of patients with hepatitis C was 30.61% (45 out of 147 selected risky groups). 35 male and 10 female patients (mean age: 71±9.6) were included. Classifying according to the type of leprosy, 29 (5.57% out of 503) were patients with epromatous leprosy and 16 (11.94% out of 134) were those with tuberculoid leprosy. Genotypic result for 41 patients was 1b in 16 (39.02%),
2a in 20 (48.78%), other type in 3 (7.32%) and mixed in 2 (4.88%). Only 2 of the patients (4.40%) had experienced blood transfusion before 1990, 20 (44.40%) had taken an operation or tattooing, 3(6.67%) were given intravenous drugs, 2 (4.44%) were family members as married couple, and as much as 20 (44.40%) had no previously known possible risk factors.
Conclusions
: Major genotype of hepatitis C in leprous patients was 2a and it is different from that of other Korean population without leprosy (p-value= 0.0027). The percentage of patients with hepatitis C was not related to the subclass of the leprosy. Further studies for the non-blood transmission of hepatitis C virus in them and its controls are needed.(Korean J Med 70:11-16, 2006)
Key Words : Hepatitis C, Hepatitis C virus genotype, Leprosy |
| Key Words:
Hepatitis C, Hepatitis C virus genotype, Leprosy |
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