Pharmacological characteristics of sulfonylureas
| Drugs | Dose range (mg) | Duration (hr) | Dosage/day (T) | Metabolism/Excretion |
|---|---|---|---|---|
| First generations | ||||
| Tolbutamide | 500-3,000 | 6-12 | 2-3 | Hepatic with renal excretion |
| Chlorpropamide | 100-500 | 24-72 | 1 | Renal excretion (30%), Some hepatic metabolism |
| Second generation | ||||
| Glipizide | 2.5-40 | 16-24 | 1-2 | Hepatic, renal excretion of inactive metabolites |
| Glibenclamide | 1.25-20 | 12-24 | 1-2 | Hepatic, renal excretion of inactive metabolites |
| Glimepiride | 1-8 | 12-24 | 1 | Hepatic with renal excretion of active metabolites |
| Gliquidone | 15-60 | 8-10 | 1-2 | Hepatic with renal excretion of inactive metabolites |
| Gliclazide | 40-320 | 10-15 | 1-2 | Hepatic with renal excretion of inactive metabolites |