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Korean J Med > Volume 88(6); 2015 > Article
알레르기
The Korean Journal of Medicine 2015;88(6): 732-736.
아스피린과민성 환자에서 메페리딘에 의해 유발된 알레르기 반응 1예
서민교1, 노태훈1, 정희정1, 김용완2, 김용한3, 정재원4, 박찬선1
1인제대학교 의과대학 해운대백병원 내과
2인제대학교 의과대학 해운대백병원 이비인후과
3인제대학교 의과대학 해운대백병원 마취통증의학과
4인제대학교 일산백병원 내과
Allergic Reaction to Meperidine in a Patient with Aspirin Idiosyncrasy
Min Gyo Seo1, Tae Hoon No1, Heui Jeong Jeong1, Young Wan Kim2, Young Han Kim3, Jae Won Jung4, Chan Sun Park1
1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
2Department of Otorhinolaryngology-Head and Neck Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
3Department of 1Internal Medicine, Anesthesiology and Pain Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
4Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea
Corresponding Author: Chan Sun Park ,Tel: +82-51-797-2211, Fax: +82-51-797-2212, Email: chansun@paik.ac.kr
Received: January 28, 2014;   Revised: August 19, 2014;   Accepted: October 29, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Although narcotic analgesics are potent releasers of histamine, IgE-mediated allergic reactions to these drugs are rare. Here we report the case of a 56-year-old male who suffered from chronic urticarial and analgesics-induced skin rashes. He visited our allergy clinic to determine alternative analgesics before undergoing surgery. A drug provocation test showed a positive reaction to aspirin, but negative reactions to acetaminophen and celecoxib. Despite careful attention to his drug regimen, during surgery he developed generalized urticaria and flushing. Skin tests of allergy to latex, lidocaine, propofol, rocuronium, flomoxef, meperidine, palonosetron, pyridostigmine, and fentanyl yielded negative results, except for the prick and intradermal tests with meperidine. Thus, this patient had both an aspirin/non-steroidal anti-inflammatory drugs idiosyncrasy and an IgE-mediated hypersensitivity to meperidine.
Keywords: Hypersensitivity; Aspirin; Meperidine; Urticaria
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