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Korean J Med > Volume 88(6); 2015 > Article
혈액종양
The Korean Journal of Medicine 2015;88(6): 715-718.
메토트렉세이트 사용 중 발생한 간을 침범한 광범위큰B세포림프종 1예
천재영1, 최희승2, 조세희1, 이서희1, 조미옥1, 이민영1, 김유리1
1연세대학교 의과대학 강남세브란스병원 내과
2연세대학교 의과대학 강남세브란스병원 병리과
A Case of Diffuse Large B-cell Lymphoma with Liver Involvement in a 67-Year-Old Woman Given Methotrexate for Rheumatoid Arthritis
Jae Young Cheon1, Hee Seung Choi2, Se Hee Jo1, Seohui Lee1, Mi Ok Cho1, Min-Young Lee1, Yu Ri Kim1
1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
2Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Corresponding Author: Yu Ri Kim ,Tel: +82-2-2019-3503, Fax: +82-2-3463-3882, Email: glassy@yuhs.ac
Received: June 26, 2014;   Revised: August 25, 2014;   Accepted: September 25, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Prolonged inflammation or immunosuppression may cause lymphoproliferative disorders (LPD). Rheumatoid arthritis (RA) itself causes LPD. The immunosuppressive drug methotrexate (MTX) is used widely to treat RA, and is also related to the development of lymphoma. Although the detailed pathogenesis and association are still controversial, care is needed when managing patients with RA treated with MTX. Many reports indicate that discontinuing MTX can induce the regression of LPD. Here, we describe a case of diffuse large B-cell lymphoma that presented with liver involvement in a 67-year-old woman who had used MTX for RA for 15 years.
Keywords: Methotrexate; Diffuse large B-cell lymphoma; Rheumatoid arthritis
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