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Korean J Med > Volume 88(1); 2015 > Article
The Korean Journal of Medicine 2015;88(1): 101-105.
췌장 신경 내분비종양에서 sunitinib과 고중성지방혈증
유상훈, 우인숙, 정윤화, 김교희, 조영윤, 한치화
가톨릭대학교 의과대학 내과학교실
Hypertriglyceridemia Associated with Use of Sunitinib to Treat a Metastatic Pancreatic Neuroendocrine Tumor
Sanghoon Yoo, Insook Woo, Yun hwa Jung, Gyohui Kim, Youngyun Cho, Chi wha Han
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Corresponding Author: Chi wha Han ,Tel: +82-2-3779-2428, Fax: +82-2-780-3132, Email: cwhan@unitel.co.kr
Received: January 8, 2014;   Revised: March 27, 2014;   Accepted: April 7, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sunitinib is a multi-target tyrosine kinase inhibitor used to treat gastrointestinal stromal tumors, renal cell carcinoma, and pancreatic neuroendocrine tumors. The most common adverse reactions are known to be nausea, fatigue, diarrhea, stomatitis, esophagitis, hypertension, skin toxicity (hand-foot syndrome), hypothyroidism, and reduction in the cardiac output of the left ventricle. Herein, we report the case of a 57 year-old female who visited our hospital complaining of epigastric pain. She had been taking sunitinib at 25 mg/day to treat a metastatic pancreatic neuroendocrine tumor. Upon computed tomography performed on admission, we observed that fluid had collected around the pancreas. Laboratory analysis revealed hypertriglyceridemia (triglycerides 993 mg/dL). Tyrosine kinase inhibitors are known to have limited effects on lipid metabolism. In this case, we suggest that hyperglycemia seems to have had a limited effect on lipid levels. We are rather of the view that hyperglycemia, a history of distal pancreatectomy, and hypothyrodisim, indirectly caused the observed hypertriglyceridemia.
Keywords: Sunitinib; Hypertriglyceridemia; Neuroendocrine tumor; Hypothyroidism
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