The Korean Journal of Medicine 2015;88(1):78-82.
Published online January 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.1.78   
A Case of Pituitary Macroadenoma Concurrently Diagnosed in a Patient Undergoing Antipsychotic Treatment
Bong Sun Kim, Joo Sung Kim, Hyong Kyu Ryu, Jin Woong Park, Sun A Hyun, Je Wook Kang, Yong Jun Choi
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea
항정신병 약제 치료 중 동반된 프로락틴 분비 뇌하수체 거대선종 치료 1예
김봉선, 김주성, 류형규, 박진웅, 현선아, 강제욱, 최용준
아주대학교 의과대학 내분비대사내과학교실
Correspondence: 
Yong Jun Choi, Tel: +82-31-219-4491, Fax: +82-31-219-4497, Email: colsmile@hanmail.net
Received: 23 January 2014   • Revised: 26 May 2014   • Accepted: 27 June 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Antipsychotics are the drug of choice for patients with schizophrenia, but they can induce hyperprolactinemia and growth of pituitary adenomas by blocking dopamine 2 receptors in the pituitary gland. In contrast, the medical treatment for a prolactinoma is a dopamine agonist. Therefore, managing a patient concurrently diagnosed with a prolactinoma and psychosis is challenging. We describe a patient with schizophrenia who was diagnosed with a prolactinoma. We changed his neuroleptic to quetiapine and prescribed bromocriptine for the prolactinoma. As a result, the patient was successfully treated with a dopamine agonist and antipsychotic without psychotic exacerbation. Our case suggests that dopamine agonists can be administrated to patients with schizophrenia and a prolactinoma without adversely affecting their psychopathological status.
Key Words: Prolactinoma; Bromocriptine; Antipsychotic agents


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