The Korean Journal of Medicine 2015;88(1):60-63.
Published online January 1, 2015.
DOI: https://doi.org/10.3904/kjm.2015.88.1.60   
Photodynamic Therapy Followed by Left Hepatectomy Used to Treat an Intraductal Papillary Mucinous Neoplasm of the Bile Duct
Hee Seung Lee, Tak Geun Oh, Moon Jae Chung, Jeong Youp Park, Seung min Bang, Si Young Song, Seung Woo Park
Division of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
광역학 치료 후 간 좌엽절제술이 가능하였던 담관 내 유두상 점액 종양 1예
이희승, 오탁근, 정문재, 박정엽, 방승민, 송시영, 박승우
연세대학교 의과대학 세브란스병원 소화기내과
Correspondence: 
Seung Woo Park, Tel: +82-2-2228-1964, Fax: +82-2-2227-7900, Email: swoopark@yuhs.ac
Received: 3 February 2014   • Revised: 13 April 2014   • Accepted: 4 August 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mucin-hypersecreting bile duct tumors, which closely resemble intraductal papillary mucinous neoplasms of the pancreas, are rare, and both the clinical features and management thereof are poorly understood. As the biliary tract and the pancreas share a common origin, the two diseases may exhibit homologous histopathological features. Certain intraductal papillary tumors of the bile duct are associated with production of large amounts of mucin that disturb bile flow and cause severe biliary dilatation, obstructive jaundice, and cholangitis. Herein, we report on a patient with an extensive intraductal papillary mucinous neoplasm of the bile duct, involving both the right and left intrahepatic ducts. The ducts were subjected to photodynamic therapy, followed by left hepatectomy. The surgical specimen revealed an adenocarcinoma with a negative resection margin. Photodynamic therapy of the intrahepatic ducts was well-tolerated in the present case, and may serve as a useful therapeutic option for selected patients with intraductal papillary mucinous neoplasms of the bile duct.
Key Words: Bile duct neoplasms; Photodynamic therapy


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