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Korean J Med > Volume 87(4); 2014 > Article
The Korean Journal of Medicine 2014;87(4): 484-490.
초기 절제술 16년 후 다발성 원격 전이된 악성 부신경절종 1예
문을선1, 민혜숙1, 정창호1, 최종현1, 김준석1, 류혜진1, 최상룡2
1고려대학교 의과대학 내과학교실
2고려대학교 의과대학 외과학교실
A Case Report of Recurrent Malignant Paraganglioma with Lung and Spine Metastasis that Occurred Sixteen Years after Primary Tumor Excision
Eul Sun Moon1, Hye Sook Min1, Chang Ho Jung1, Jong Hyun Choi1, Jun Suk Kim1, Hye Jin Yoo1, Sang Yong Choi2
1Departments of Internal Medicine, Korea University College of Medicine, Seoul, Korea
2Departments of Surgery, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Hye Jin Yoo ,Tel: +82-2-2626-1853, Fax: +82-2-866-1643, Email: deisy21@naver.com
Received: July 24, 2013;   Revised: August 14, 2013;   Accepted: September 12, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/bync/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Paragangliomas are rare tumors that arise from the extra-adrenal chromaffin cells, and malignancy is defined by the presence of metastases to sites that normally lack chromaffin tissue. The main therapeutic targets are tumor reduction and control of excessive catecholamine secretion. Currently, the adjuvant therapy to surgery is radiotherapy treatment using high-dose MIBG; chemotherapy is currently evolving. We report herein a case of malignant paraganglioma with lung and spine metastasis that occurred 16 years after primary tumor excision and was treated with high dose MIBG radiotherapy and chemotherapy.
Keywords: Malignant paraganglioma, Lung metastasis, Spine metastasis; Metaiodobenzylguanidine; Chemotherapy
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