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Korean J Med > Volume 87(4); 2014 > Article
The Korean Journal of Medicine 2014;87(4): 389-394.
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이상헌
건국대학교 의학전문대학원 내과학교실
The New Classification Criteria of Systemic Lupus Erythematosus
Sang-Heon Lee
Division of Rheumatology, Department of Internal Medicine, Konkuk Universtiy School of Medicine, Seoul, Korea
Corresponding Author: Sang-Heon Lee ,Tel: +82-2-2030-7541, Fax: +82-2-2030-7748, Email: shlee@kuh.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/bync/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Systemic lupus erythematosus (SLE) is a prototype for multi-system, autoimmune diseases of unknown etiology, characterized by the production of autoantibodies. SLE can involve any organ system of the body with constitutional symptoms, including musculoskeletal, skin, renal, neuropsychiatric, cardiovascular, respiratory and gastrointestinal systems. These wide spectra of disease manifestations have made disease classification difficult. American College of Rheumatology (ACR) proposed classification criteria for SLE for research purpose in 1982, which had been widely used for research purpose and not for diagnosis. In 1997, these criteria were updated with further recognition of antiphospholipid antibodies, but not validated. But ACR criteria didn't still meet the necessity for earlier diagnosis of SLE. In order to improve clinical relevance and incorporate new knowledge to the field of lupus immunology, the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC), an international lupus expert group dedicated to clinical research on lupus, revised the ACR systemic lupus classification criteria in 2012. The new 2012 SLICC criteria were validated using a large set of patient scenarios rated by experts. The history and diagnostic utility of SLE criteria are covered in this review.
Keywords: Systemic lupus erythematosis; Diagnosis
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