Korean J Med > Volume 87(3); 2014 > Article
The Korean Journal of Medicine 2014;87(3):323-327.
Published online September 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.87.3.323   
A Case of Hyponatraemic Seizure Following Terlipressin Therapy fora Variceal Hemorrhage in a Patient with Liver Cirrhosis
Jin-Hee Kim, Ja-Kyung Kim, So-Yeong Mun, Chung-Jo Choi, Han-Min Park, Yong-Seol Jeong, Jun Goo Kang
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea
Terlipressin 투여 후 발생한 저나트륨혈증에 의한 간질발작 1예
김진희, 김자경, 문소영, 최청조, 박한민, 정용설, 강준구
한림대학교 의과대학 내과학교실
Correspondence: 
Jun Goo Kang, Tel: +82-31-380-3700, Fax: +82-31-383-3768, Email: kjg0804@empal.com
Received: 11 September 2013   • Revised: 23 October 2013   • Accepted: 26 November 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Terlipressin has splanchnic vasoconstrictive effects, and is generally used for the management of gastroesophageal variceal bleeding secondary to liver cirrhosis. Terlipressin is a synthetic arginine vasopressin (AVP) analog containing a nonapeptide sequence. Terlipressin has increased selectivity for the V1 receptor, compared with AVP; hence, it is considered to be a safe vasoconstrictor. However, side effects such as hyponatremia and seizure, although very rare, have been reported. Hyponatremia related to terlipressin may be caused by the syndrome of inappropriate antidiuresis (SIAD), which is a disorder of sodium and water balance characterized by hypotonic hyponatremia without elevation of the antidiuretic hormone level. Here, we report a case of hyponatremic seizure induced by an infusion of terlipressin in a 52-year-old female who had isolated gastric variceal bleeding secondary to alcoholic liver cirrhosis.
Key Words: Terlipressin; Hyponatremia; Seizure
주제어: Terlipressin; 저나트륨혈증; 발작


TOOLS
METRICS Graph View
  • 1 Crossref
  •  0 Scopus
  • 3,164 View
  • 27 Download

Editorial Office
101-2501, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-2271-6791    Fax: +82-2-790-0993    E-mail: kaim@kams.or.kr                

Copyright © 2024 by The Korean Association of Internal Medicine.

Developed in M2PI

Close layer
prev next