A Case of Hyponatraemic Seizure Following Terlipressin Therapy fora Variceal Hemorrhage in a Patient with Liver Cirrhosis |
Jin-Hee Kim, Ja-Kyung Kim, So-Yeong Mun, Chung-Jo Choi, Han-Min Park, Yong-Seol Jeong, Jun Goo Kang |
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea |
Terlipressin 투여 후 발생한 저나트륨혈증에 의한 간질발작 1예 |
김진희, 김자경, 문소영, 최청조, 박한민, 정용설, 강준구 |
한림대학교 의과대학 내과학교실 |
Correspondence:
Jun Goo Kang, Tel: +82-31-380-3700, Fax: +82-31-383-3768, Email: kjg0804@empal.com |
Received: 11 September 2013 • Revised: 23 October 2013 • Accepted: 26 November 2013 |
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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Abstract |
Terlipressin has splanchnic vasoconstrictive effects, and is generally used for the management of gastroesophageal variceal bleeding secondary to liver cirrhosis. Terlipressin is a synthetic arginine vasopressin (AVP) analog containing a nonapeptide sequence. Terlipressin has increased selectivity for the V1 receptor, compared with AVP; hence, it is considered to be a safe vasoconstrictor. However, side effects such as hyponatremia and seizure, although very rare, have been reported. Hyponatremia related to terlipressin may be caused by the syndrome of inappropriate antidiuresis (SIAD), which is a disorder of sodium and water balance characterized by hypotonic hyponatremia without elevation of the antidiuretic hormone level. Here, we report a case of hyponatremic seizure induced by an infusion of terlipressin in a 52-year-old female who had isolated gastric variceal bleeding secondary to alcoholic liver cirrhosis. |
Key Words:
Terlipressin; Hyponatremia; Seizure |
주제어:
Terlipressin; 저나트륨혈증; 발작 |
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