Hodgkin’s Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma

Park, Su-Youn; Yu, Hyung Min; Kim, Jiwan; An, Sang Hee; Kim, Wook Youn; Hur, Mina; Lee, Hong Gi

doi:2014.86.6.774

Korean J Med > Volume 86(6); 2014 > Article

Case Report

The Korean Journal of Medicine 2014;86(6):774-780.
Published online June 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.6.774

Hodgkin’s Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma

Su-Youn Park¹, Hyung Min Yu¹, Jiwan Kim¹, Sang Hee An¹, Wook Youn Kim², Mina Hur³, Hong Gi Lee¹

¹Departments of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
²Departments of Pathology, Konkuk University School of Medicine, Seoul, Korea
³Departments of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea

자가조혈모세포 이식 후 발생한 호지킨림프종

박수연¹, 유형민¹, 김지완¹, 안상희¹, 김욱연², 허미나³, 이홍기¹

^¹건국대학교 의학전문대학원 내과학교실
^²건국대학교 의학전문대학원 병리학교실
^³건국대학교 의학전문대학원 진단검사의학교실

Correspondence:
Hong Gi Lee, Tel: +82-2-2030-7538, Fax: +82-2-2030-7458, Email: mlee@kuh.ac.kr

Received: 5 July 2013 • Revised: 12 August 2013 • Accepted: 2 October 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin’s lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea. (Korean J Med 2014;86:774-780)

Key Words: Lymphoproliferative disorder; Hodgkin disease; Hematopoietic stem cell transplantation; Epstein-Barr virus

주제어: 림프증식성 질환; 호지킨림프종; 조혈모세포이식; 엡스테인-바바이러스