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Korean J Med > Volume 86(2); 2014 > Article
The Korean Journal of Medicine 2014;86(2): 242-246.
동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후 골수 무형성증 1예
윤현화1, 홍준식1, 김수영1, 이동민1, 박진희1, 안정열2, 이재훈1
1가천대학교 의학전문대학원 내과
2가천대학교 의학전문대학원 진단검사의학과
Acute Myeloid Leukemia with Persistent Marrow Aplasia after Chemotherapy Treated with Reduced-Intensity Allogeneic Stem Cell Transplantation
Hyunhwa Yoon1, Junshik Hong1, Suyoung Kim1, Dongmin Lee1, Jinny Park1, Jeong Yeal Ahn2, Jae Hoon Lee1
1Departments of Internal Medicine, Gachon University School of Medicine, Incheon, Korea
2Departments of Laboratory Medicine, Gachon University School of Medicine, Incheon, Korea
Corresponding Author: Junshik Hong ,Tel: +82-32-460-3229, Fax: +82-32-460-3233, Email: alertjun@hanmail.net
Received: March 18, 2013;   Revised: May 2, 2013;   Accepted: August 12, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Persistent bone marrow aplasia after intensive chemotherapy is uncommon, but is one of the fatal complications in patients with acute myeloid leukemia (AML). Although allogeneic hematopoietic stem cell transplantation (HSCT) is considered to be contraindicated for patients who have hematologic diseases with serious infections, such as bacterial septicemia or invasive fungal diseases, combined with prolonged neutropenia due to frequent morbidity and mortality, such risks can be overcome by non-myeloablative conditioning and best supportive care. Here, we report an AML patient with persistent marrow aplasia after induction therapy, treated successfully with reduced-intensity allogeneic HSCT despite severe bacterial and fungal infections. (Korean J Med 2014;86:242-246)
Keywords: Acute myeloid leukemia; Stem cell transplantation; Aplastic anemia; Neutropenia; Chemotherapy
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Endobronchial Relapse of Acute Myeloid Leukemia after Allogeneic Stem Cell Transplantation  2013 September;85(3)
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