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Korean J Med > Volume 86(2); 2014 > Article
The Korean Journal of Medicine 2014;86(2): 169-178.
고중성지방혈증과 복부비만이 관상동맥 중재술을 시술받은 급성 심근경색증 환자의 임상경과에 미치는 영향
한수경1,2, 정명호1,2,4, 이정애3, 최진수3, 이기홍1,2,4, 박근호1,2,4, 심두선1,2,4, 홍영준1,2,4, 김주한1,2,4, 안영근1,2,4, 조정관1,2,4, 박종춘1,2, 강정채1,2
1전남대학교병원 심장센터
2보건복지부 지정 심장질환 특성화 연구센터
3전남대학교 의과대학 예방의학교실
4한국심혈관스텐트연구소
Clinical Impact of High Triglycerides and Central Obesity in Patients with Acute Myocardial Infarction who Underwent Percutaneous Coronary Intervention
Soo Gyoung Han1,2, Myung Ho Jeong1,2,4, Jung Ae Rhee3, Jin Su Choi3, Kee Hong Lee1,2,4, Keun Ho Park1,2,4, Doo Sun Sim1,2,4, Young Joon Hong1,2,4, Ju Han Kim1,2,4, Young Keun Ahn1,2,4, Jeong Gwan Cho1,2,4, Jong Chun Park1,2, Jung Chaee Kang1,2
1The Heart Center of Chonnam National University Hospital, Gwangju, Korea
2The Heart Research Center Designated by Korea Ministry of Health and Welfare, Gwangju, Korea
3Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea
4Korea Cardiovascular Stent Research Institute, Chonnam National University, Gwangju, Korea
Corresponding Author: Myung Ho Jeong ,Tel: +82-62-220-6243, Fax: +82-62-228-7174, Email: myungho@chollian.net
Received: November 3, 2012;   Revised: November 26, 2012;   Accepted: February 13, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Background/Aims:
Dyslipidemia and obesity are risk factors for the development of acute myocardial infarction (AMI) that affect the clinical outcomes in patients.
Methods:
We analyzed 2,751 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) (mean age, 63.7 ± 12.1 years). The patients were divided into four groups based on serum triglyceride levels and central obesity [Group Ia: triglycerides < 200 mg/dL and (-) central obesity; Group Ib: triglyceride < 200 mg/dL and (+) central obesity; Group IIa: triglyceride ≥ 200 mg/dL and (-) central obesity; Group IIb: triglyceride ≥ 200 mg/dL and (+) central obesity]. In-hospital outcome was defined as in-hospital mortality and complications. One-year clinical outcome was compared and defined as the composite of 1-year major adverse cardiac events (MACE), including death, recurrent MI, and target vessel revascularization.
Results:
Total MACE developed in 502 patients (18.2%), while 303 patients (11.0%) died prior to the 1-year follow-up visit. In-hospital complications and in-hospital mortality were not different among the four groups. One-year clinical outcomes based on triglyceride levels (Group I vs. Group II) were not different. In addition, there were no differences in clinical outcomes in patients with a triglyceride level < 200 mg/dL, regardless of central obesity. One-year MACE rates were not significantly different among the four groups.
Conclusions:
There was no significant difference in the 1-year MACE rate based on the triglyceride level and presence of central obesity in patients with AMI who underwent PCI. (Korean J Med 2014;86:169-178)
Keywords: Acute myocardial infarction; Obesity; Triglyceride; Mortality
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