Korean J Med > Volume 80(2); 2011 > Article
The Korean Journal of Medicine 2011;80(2):183-187.
A Case of Interstitial Pneumonitis Induced by Acitretin
Sung Du Kim1, Yoon Jeong Kim1, Seouk Chan Ko1, Ho Jun Lee1, Jae-Phil Choi1, Heon Lee2, Suhyun Kim1
아시트레틴 투여로 발생한 간질성 폐렴 1예
김성두1, 김윤정1, 고석찬1, 이호준1, 최재필1, 이헌2, 김수현1
Abstract
Retinoids are effective systemic agents in the treatment of psoriasis. Acitretin, a synthetic aromatic derivative of retinoic acid, has replaced etretinate in retinoid therapy of psoriasis because of its more favorable pharmacokinetic profile, including a significantly shorter half-life. Most of the adverse effects associated with acitretin are teratogenicity, hepatotoxicity, pseudotumor cerebri, pancreatitis, hyperlipidemia, hyperostosis, and mucocutaneous side effects. There are two reports worldwide describing patients who developed acute respiratory distress syndrome associated with acitretin. This suggests the possibility of serious lung complications associated with acitretin. We report a case of a 61-year-old man who developed interstitial pneumonitis that might have been induced by acitretin during the treatment of pustular psoriasis. In these cases, immediate withdrawal of retinoic acid is necessary, and corticosteroid therapy should be considered.
Key Words: Acitretin; Interstitial pneumonitis; Pustular psoriasis


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