A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia

Sang Eon Jang,; Hye Jin Kang,; Yoon Hwan Chang,; Dong Soon Lee,; Hyeon Tae Kim,; Kyung Won Koh,; Sung Hyun Yang,

Korean J Med > Volume 78(3); 2010 > Article

Original Article

The Korean Journal of Medicine 2010;78(3):386-390.

A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia

Sang Eon Jang, Hye Jin Kang, Yoon Hwan Chang, Dong Soon Lee, Hyeon Tae Kim, Kyung Won Koh, Sung Hyun Yang

호산구증가증과 PDGFRB 유전자 재배열을 보인 골수종양 1예

장상언, 강혜진, 장윤환, 이동순, 김현태, 고경원, 양성현

Abstract

Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib. (Korean J Med 78:386-390, 2010)

Key Words: Myeloid neoplasm; PDGFRB rearrangement; Eosinophilia; Imatinib mesylate