| A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment |
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Ki Deok Yoo, Jong Heon Jeong, Soo-Kyung Cho, Gheun-Ho Kim, Ho Soon Choi, Dong Sun Kim, Jae-Bum Jun |
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| 저용량 adefovir dipivoxil에 의한 저인산염혈증과 다발성 근육통 1예 |
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유기덕, 정종헌, 조수경, 김근호최호순, 김동선, 전재범, Jae-Bum Jun |
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| Abstract |
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Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV. (Korean J Med 78:261-265, 2010) |
| Key Words:
Adefovir dipivoxil; Nephrotoxicity; Hypophosphatemia; Osteomalacia |
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