| Combination therapy of hypertension |
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Gil Ja Shin |
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1동아대학교 의과대학 내과학교실, 2부산의료원 신장내과 |
| 고혈압 약제의 병용요법 |
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신길자 |
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1Department of Internal Medicine, Dong-A University College of Medicine; 2Division of Nephrology, Busan Medical Center, Busan, Korea |
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| Abstract |
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Hypertension is one of the most common preventable disease for premature death in worldwide. In Korea, the prevalence rate of hypertension is 24.9% in adult. The pathophysiology of the hypertension is complicated including genetics, aging, sympathetic nervous system, renin-angiotensin-aldosterone system, metabolism and nutrition. The combination therapy for blocking these complex systems is effective. Recent clinical studies showed angiotensin converting enzyme inhibitor and calcium channel blocker was more effective than the old drug combination such as beta blocker and diuretics. For improving compliance, fixed-dose drug combination is recommended. For the effect of treatment, simple guideline is essential. (Korean J Med 78:177-184, 2010) |
| Key Words:
Combination therapy; Hypertension |
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