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The Korean Journal of Medicine 2009;77(1): 157-161.
파종혈관내응고, 뇌경색, 급성 호흡부전으로 발현된 파국성 항인지질증후군
손경민, 윤종우, 박인일, 양하나, 김병호, 최명진, 구자룡
Catastrophic antiphospholipid syndrome presenting with disseminated intravascular coagulation, cerebral infarction, and acute respiratory distress syndrome
Kyoung Min Sohn, Jong Woo Yoon, In Il Park, Ha Na Yang, Byoung Ho Kim, Myung Jin Choi, Ja Ryong Koo
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial or venous thrombosis and recurrent fetal loss accompanied by elevated titers of antiphospholipid antibodies. Catastrophic APS is a small subset of APS, characterized by widespread systemic thrombotic disease with multiorgan failure. The diagnosis of catastrophic APS may be difficult, predominantly due to its frequently atypical presentation. In the present work, we describe a case of a 68-year-old male who presented with cerebral infarction, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome. The patient was successfully treated with anticoagulants, antibiotics, and steroid therapy. Physicians should be aware of the possibility of this syndrome as a cause of DIC with thrombotic disease because prompt recognition is essential for effective treatment.
Keywords: Antiphospholipid syndrome; Disseminated intravascular coagulation; Acute respiratory distress syndrome
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Catastrophic Antiphospholipid Syndrome Improved by Anticoagulation Alone  2011 June;80(2)
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