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The Korean Journal of Medicine 2009;77(3): 362-366.
장기간의 한랭 응집소병 경과 중 발생한 small lymphocytic lymphoma
김진영·박우영·이상민·김주연·이형기·김윤정·권기영, , , , , ,
Small lymphocytic lymphoma that developed in a patient with long-standing cold agglutinin disease
Jin Young Kim, Woo Young Park, Sang Min Lee, Ju Youn Kim, Hyung Ki Lee, Yun Jung Kim, Ki Young Kwon
ABSTRACT
Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia (AIHA) induced by cold antibodies. CAD constitutes 16~32% of AIHA cases and the causative cold autoantibodies are commonly specific against blood group I or i antigens. CAD is closely related to lymphoid neoplasia and infections such as Mycoplasma and Epstein-Barr virus (EBV). Primary CAD has a tendency to develop into malignant lymphoma over its course. We experienced a case of small lymphocytic lymphoma during the treatment of primary CAD over 11 years. The patient was a 67-year-old man who complained of a neck mass. Node biopsy revealed diffuse neoplastic proliferation of small monotonous lymphoid cells with polygonal or oval nuclei; these cells were CD20- and CD5-positive. Follow-up chest and neck computed tomography after treatment with chlorambucil and prednisolone showed partial resolution and stable disease status for over 2 years. We report a case of small lymphocytic lymphoma that developed in a patient with long-standing cold agglutinin disease for 11 years and review the literature. (Korean J Med 77:362-366, 2009)
Keywords: Anemia; Hemolytic; Autoimmune; Lymphoma; Non-Hodgkin’s
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