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The Korean Journal of Medicine 2009;77(3): 315-320.
대장용종에서 ILK (Integrin-linked kinase)와 beta-catenin의 발현
채현석·김진수·손혜숙·노상영·김형근·조영석·이보인·강진형·최규용·맹이소·장은덕, , , , , , , , , ,
Integrin-linked kinase (ILK) and β-catenin expression in colon polyps
Hiun Suk Chae, Jin Soo Kim, Hye Sook Sohn, Sang Young Rho, Hyung Keun Kim, Young Suk Cho, Bo In Lee, Jin Hyung Kang, Kyu Yong Choi, Ei So Maeng, Eun Duck Chang
ABSTRACT
Background/Aims:
Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type.
Methods:
Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22), or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with immunohistochemistry.
Results:
In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01).
Conclusions:
The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed more in TAs than in HPs, especially in severe dysplasia. (Korean J Med 77:315-320, 2009)
Keywords: Colon polyps; Integrin-linked kinase; Proteins; β-catenin
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