| Integrin-linked kinase (ILK) and β-catenin expression in colon polyps |
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Hiun Suk Chae, Jin Soo Kim, Hye Sook Sohn, Sang Young Rho, Hyung Keun Kim, Young Suk Cho, Bo In Lee, Jin Hyung Kang, Kyu Yong Choi, Ei So Maeng, Eun Duck Chang |
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| 대장용종에서 ILK (Integrin-linked kinase)와 beta-catenin의 발현 |
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채현석·김진수·손혜숙·노상영·김형근·조영석·이보인·강진형·최규용·맹이소·장은덕, Jin Soo Kim, Hye Sook Sohn, Sang Young Rho, Hyung Keun Kim, Young Suk Cho, Bo In Lee, Jin Hyung Kang, Kyu Yong Choi, Ei So Maeng, Eun Duck Chang |
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| Abstract |
Background/Aims
Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression
of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and
invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression
of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type.
Methods
Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22),
or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic
polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with
immunohistochemistry.
Results
In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology
of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both
ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin
were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01).
Conclusions
The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed
more in TAs than in HPs, especially in severe dysplasia. (Korean J Med 77:315-320, 2009) |
| Key Words:
Colon polyps; Integrin-linked kinase; Proteins; β-catenin |
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