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Recently, the management of hypertension has focused on the prevention of target organ damage to organs such as the heart, kidney,
brain, and blood vessels. To detect subclinical organ damage, several novel surrogate markers were established after amassing
considerable evidence. Left ventricular hypertrophy, diastolic dysfunction measured by echocardiography, carotid intima-media
thickness, ankle-brachial index, pulse wave velocity, central blood pressure, estimated glomerular filtration rate, and microalbuminuria
have been proposed as new parameters to detect subclinical organ damage in patients with hypertension. The European
guidelines for the management of arterial hypertension, published in 2007, suggested that risk stratification based on using new surrogate
markers was important for classifying the stage of hypertension and choosing appropriate anti-hypertensive drugs.
Therefore, these surrogate markers should be checked in the early phase of hypertension and their clinical importance considered in
daily practice. (Korean J Med 76:402-408, 2009) |
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