| The trend in the eradication rates of first- and second-line therapy for Helicobacter pylori infection in Daegu and Kyungpook provinces: a single center experience for the most recent 9 years |
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Han Jin Cho, Rack Cheon Bae, Soon Hak Lee, Sun Ik Jang, Hyun Seok Lee, So Young Choi, Keun Young Shin, Jun Heo, Sung Kook Kim, Min Kyu Jung, Seong Woo Jeon |
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| 대구, 경북 지역 Helicobacter pylori 일차 및 이차 치료의 연도별 제균율 변화 : 최근 9년 성적 |
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조한진 &#; 배락천 &#; 이순학 &#; 장선익 &#; 이현석 &#; 최소영 &#; 신근, Rack Cheon Bae, Soon Hak Lee, Sun Ik Jang, Hyun Seok Lee, So Young Choi, Keun Young Shin, Jun Heo, Sung Kook Kim, Min Kyu Jung, Seong Woo Jeon |
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| Abstract |
Background/Aims
The reported prevalence of antibiotic resistance in Helicobacter pylori infection has been increasing.
However, recent trends in the eradication rates of H. pylori using first-line triple regimens are rarely reported. Therefore,
we determined the trend in the H. pylori eradication rates in a single center for the most recent 9 years in Daegu and
Kyungpook provinces, Korea.
Methods
From January 1999 through December 2007, the eradication rates in 615 H. pylori-positive patients who
received one-week triple regimens were evaluated retrospectively according to year and ulcer location.
Results
The overall H. pylori eradication rate was 81.6%. The eradication rate from the years 1999 to 2007 was 76.3,
78.3, 82.8, 88.5, 77.8, 91.7, 84.8, 75.4, and 83.7%, respectively, based on the per-protocol analysis. No definite evidence
of a decreasing tendency of the eradication rate was seen over the 9 years (p=0.760). Furthermore, there was no significant
difference in the eradication rate according to ulcer location.
Conclusions
There is no decreasing trend in the H. pylori eradication rate over the past 9 years in Daegu and
Kyungpook provinces. However, the eradication rates are not satisfactory, and further investigation is needed to develop
more effective regimens. (Korean J Med 76:186-192, 2009) |
| Key Words:
Helicobacter pylori; First-line regimen; Eradication rates |
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