Korean J Med > Volume 75(3); 2008 > Article
The Korean Journal of Medicine 2008;75(3):870-876.
A case of anterior pituitary hormone deficiency caused by a relapsed malignant lymphoma
Yun-hyuk Yim, Hye-Jung No, Jong-Bin Park, Hyeok Shim, Byoung-Hyun Park, Moo-Rim Park, Chung-Gu Cho
증례 : 재발성 악성 림프종에 의한 뇌하수체 전엽 호르몬 감소증 1예
임윤혁.노혜정.박종빈.심 혁.박병현.박무림.조정구, Hye-Jung No, Jong-Bin Park, Hyeok Shim, Byoung-Hyun Park, Moo-Rim Park, Chung-Gu Cho
Abstract
Malignant lymphomas involving the pituitary gland are rare. We report a case of relapsed large B-cell non-Hodgkin’s lymphoma affecting the anterior pituitary gland. The patient was a 47-year-old man who presented with headache, weakness, and tingling sensation involving both lower extremities. He had achieved the complete remission of lymphoma 5 months earlier. The thyroid stimulating hormone and free thyroxine levels were decreased at the time of admission. Magnetic resonance imaging showed secondary lymphoma involving the pituitary fossa, cavernous sinus, pineal gland, and cranial nerves. The anterior pituitary hormone levels were low and lymphoma cells were detected in the cerebrospinal fluid. The patient was treated with hydrocortisone, levothyroxine, high-dose methotrexate, and intrathecal methotrexate, and achieved complete remission of the pituitary mass. Pituitary function recovered after remission of the pituitary mass. (Korean J Med 75:S870-S876, 2008)
Key Words: Malignant lymphoma; Anterior pituitary; Hypopituitarism


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