Korean J Med > Volume 75(3); 2008 > Article
The Korean Journal of Medicine 2008;75(3):827-832.
Newly diagnosed acute myeloid leukemia after complete remission lasting 16 years
Ji Young Rhee, Ki Hwan Kim, Joo-Won Min, Inho Kim, Sung-Soo Yoon, Seonyang Park, Byoung Kook Kim
증례 : 완전관해 16년 후 새로 진단된 급성골수성백혈병의 증례
이지영.김기환.민주원.김인호.윤성수.박선양.김병국 , Ki Hwan Kim, Joo-Won Min, Inho Kim, Sung-Soo Yoon, Seonyang Park, Byoung Kook Kim
Abstract
A 36-year-old woman was admitted in December 1987 because of pancytopenia. Acute myeloid leukemia (AML), French-American-British classification M4, was diagnosed. Cytogenetic analysis was not performed. She was treated with cytarabine and daunorubicin and achieved complete remission (CR). She underwent four courses of consolidation and late intensification therapy consisting of cytarabine, daunorubicin, 6-thioguanine, vincristine, and prednisolone. In December 2004, AML, French-American-British classification M1, was diagnosed. In addition, the AML1/ETO rearrangement was detected using the polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH). She was treated with cytarabine and idarubicin and achieved CR again. She underwent further consolidation therapy. In August 2005, a relapse of AML was diagnosed. She underwent reinduction chemotherapy and allogenic non-myeloablative stem cell transplantation. In January 2006, another relapse of AML was diagnosed. Despite a donor lymphocyte infusion, she died of pneumonia with leukemia progression. We present a patient with recurrent AML after CR for 16 years and 9 months. (Korean J Med 75:S827-S832, 2008)
Key Words: Acute myelocytic leukemia; French-American-British classification


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