| A case of acute drug-induced hepatotoxicity after albendazole treatment |
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Min Kwan Kim, Hye Won Park, Won Jin Kim, Chul Min Park, Ji Yeon Hong, Seung Jin Cho, Myoung Kuk Jang |
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경희대학교 의과대학 순환기내과학교실 |
| 증례: 알벤다졸(400 mg) 1회 복용에 의해 유발된 급성 독성간염 1예 |
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김민관.박혜원.김원진.박철민.홍지연.조성진.장명국 , Hye Won Park, Won Jin Kim, Chul Min Park, Ji Yeon Hong, Seung Jin Cho, Myoung Kuk Jang |
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| Abstract |
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Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole- induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only. (Korean J Med 75:564-568, 2008) |
| Key Words:
Albendazole; Hepatotoxicity |
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