Korean J Med > Volume 75(5); 2008 > Article
The Korean Journal of Medicine 2008;75(5):553-558.
Effect of the G-CSF schedule for harvesting peripheral blood progenitor cells from healthy donors
Sung Eun Lee, Jin Young Park, Sung Won Lee, Ik Jun Choi, Seok Ju Lee, Chong Won Park
울산의대 울산대학교병원 내과, 영상의학과1
원저: 건강한 공여자에서 말초조혈모세포 채집시 G-CSF의 투여기간의 효과
이성은.박진영.이승원.최익준.이석주.박종원, Jin Young Park, Sung Won Lee, Ik Jun Choi, Seok Ju Lee, Chong Won Park
Abstract
Background/Aims: Peripheral blood progenitor cells (PBSC) have been used instead of bone marrow cells for allogeneic transplantation. Progenitor cells are mobilized using granulocyte colony stimulating factor (G-CSF). Kinetic studies of G-CSF have shown that the CD34+ cells peak on day 5, although the optimal time for harvesting has not been established. Methods: We compared two mobilization schedules using G-CSF. In groups I and II, G-CSF 10 µg/kg/day was administered subcutaneously for 3 or 4 days, respectively, and leukapheresis was performed the next day. Results: In groups I and II, a respective mean number of 5.84 × 106 and 10.76 × 106 circulating CD34+ cells per kilogram of the recipient’s weight was collected by leukapheresis. The yield of the two collections did not differ significantly (p=0.386). Conclusion: This study suggested that the two mobilization schedules are equally effective. To avoid prolonged exposure to G-CSF, the day 4 collection schedule is the preferred mobilization strategy. (Korean J Med 75:553-558, 2008)
Key Words: Peripheral blood stem cells; Mobilization; Granulocyte colony-stimulating factor; Healthy donor


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