Korean J Med > Volume 75(3); 2008 > Article
The Korean Journal of Medicine 2008;75(3):300-306.
Usefulness of the serum Helicobacter pylori IgG antibody test during routine check-up
Jung Hyun Kwon, Myung Gyu Choi, Won Hang Huh, Jung Pil Suh, Kwan Woo Nam, Jae Hyuck Chang, Jae Myung Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, In-Sik Chung
을지의과대학교 내과학교실1, 흉부외과학교실2, 영상의학교실3, 병리학교실5
원저: 검진센터에서 헬리코박터 필로리 혈청 IgG 항체 검사가 필요한가?
권정현&#;최명규&#;허원행&#;서정필&#;남관우&#;장재혁&#;박재명&#;조유경&#;이인, Myung Gyu Choi, Won Hang Huh, Jung Pil Suh, Kwan Woo Nam, Jae Hyuck Chang, Jae Myung Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, In-Sik Chung
Abstract
Background/Aims: The serum Helicobacter pylori IgG antibody test has been widely used by primary care physicians for over two decades. We assessed its usefulness as a screening strategy for organic gastrointestinal disease in routine check-up. Methods: We retrospectively reviewed the medical records of 10,080 subjects who received a routine check up at the Kangnam St. Mary’s Hospital from January 2004 to April 2005. All subjects underwent the H. pylori IgG antibody test and upper gastrointestinal endoscopy or a barium contrast study. Results: The overall seropositive rate for H. pylori detection was 61.0% (6,150/10,180). The 13C-urea breath test (UBT) was performed in 340 subjects. The H. pylori antibody test showed 55% accuracy in comparison to the standard 13C-UBT. The number of patients with peptic ulcer in the seropositive group was 475 (7.7%) compared to only 168 patients (4.3%) in the seronegative group (p<0.001). Stomach cancer was observed in eight (0.1%) and two (0.1%) patients in the seropositive and seronegative groups, respectively. The positive and negative likelihood ratios for the H. pylori IgG antibody test for peptic ulcer were 1.22 and 0.66, respectively, compared to 1.31 and 0.26 for stomach cancer. Conclusions: In view of its low accuracy and likelihood ratios, we do not recommend the H. pylori antibody test as a diagnostic tool for H. pylori infection or as a screening strategy for organic gastrointestinal disease during routine check-ups. (Korean J Med 75:300-306, 2008)
Key Words: Helicobacter pylori; Serologic test; Peptic ulcer; Stomach cancer; Screening test


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