| A case of chronic respiratory insufficiency caused by polyneuropathy associated with monoclonal gammopathy of undetermined significance |
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Chae Young Lim, Oh Sung Kwon, Jung Ho Choi, Dae Rim Park, Byoung Hoon Lee, Sang Hoon Kim, Jeong Don Chae |
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경희대학교 의과대학 순환기내과학교실 |
| 증례 : MGUS와 동반된 다발성신경병증에서 발생한 만성호흡부전 1예 |
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임채영, 권오성, 최정호, 박대림, 이병훈, 김상훈, 채정돈 |
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| Abstract |
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Peripheral neuropathy, such as paraproteinemic neuropathy, is a rare neuromuscular cause of chronic ventilatory failure. Monoclonal gammopathy of undetermined significance (MGUS) is the most common cause of paraproteinemic neuropathy. We report a case of chronic ventilatory failure caused by polyneuropathy associated with MGUS. An 82-year-old man with no history of respiratory or cardiac disease visited our hospital with progressive generalized weakness and dyspnea for 6 months. Arterial blood gas analysis showed partially compensated chronic respiratory acidosis, and maximal voluntary ventilation was markedly decreased on pulmonary function testing. Nerve conduction studies and electromyography revealed diffuse sensorimotor polyneuropathy. Blood and urine protein electrophoresis and bone marrow biopsy showed IgG kappa type of MGUS. The patient was successfully supported with a non-invasive mechanical ventilator at night, and on an as-needed basis. |
| Key Words:
Benign monoclonal gammopathy; Polyneuropathy; Respiratory insufficiency |
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