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The Korean Journal of Medicine 2008;74(6): 605-610.
원저 : Helicobacter pylori 감염과 대장 신생물 발생의 관련성
홍은정, 박동일, 손희정, 배문희, 김화목, 김용성, 변선정, 박정호, 김홍주, 조용균, 손정일, 전우규, 김병익
Correlations between the prevalence of colonic neoplasia and Helicobacter pylori infection
Eun Jung Hong, Dong Il Park, Hee Jung Sohn, Mun Hee Bae, Hwa Mock Kim, Yong Sung Kim, Sun Jeong Byun, Jung Ho Park, Hong Joo Kim, Yong Kyun Cho, Chong Il Shon, Woo Kyu Jeon,
Department of Pulmonology and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea
Background/Aims : Helicobacter pylori infection is a recognized cause of chronic gastritis, peptic ulcer and gastric adenocarcinoma. However, both positive and negative associations with colorectal neoplasia have been reported. The aim of this study was to determine whether H. pylori infection is associated with an increased risk of colonic neoplasia in a Korean population. Methods : We examined 1,590 subjects (1,297 men and 293 women) who underwent colonoscopy and serologic testing for IgG antibodies against H. pylori at the Health promotion Center in Kangbuk Samsung Hospital and at Samsung Medical Center. We compared the prevalence of colonic neoplasia in the seropositive subjects with that of the seronegative subjects. Results : The overall prevalence of H. pylori in our study population was 56.2%. There were no significant differences of the baseline characteristics between the two groups. There was no statistically significant difference in the prevalence of colonic neoplasia between the seropositive group and the seronegative group (p=0.090). Conclusions : These findings suggest that there is no significant association between H. pylori infection and colonic neoplasia.
Keywords: Helicobacter pylori; Colonic neoplasia
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