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The Korean Journal of Medicine 2008;74(4): 445-450.
증례 : 타인 동종 말초혈액 조혈모세포이식 후 발생한 공기-누출 증후군 1예
김시현, 신주영, 황현석, 김대준, 김희제, 민우성, 김춘추
Air-leakage syndrome after allogeneic peripheral blood stem cell transplantation from unrelated donor
Si-Hyun Kim, Ju-Young Shin, Hyun-Suk Hwang, Dae-Jun Kim, Hee-Je Kim, Woo-Sung Min, Chun-Choo Kim
경희대학교 의과대학 순환기내과학교실
Bronchiolitis obliterans, a late, non-infectious pulmonary complication of bone marrow transplantation (BMT), is an obstructive airway disease associated with chronic graft-versus-host disease (cGVHD). We report a rare case of air-leakage syndrome including pneumothoraces, pneumomediastinum, and subcutaneous emphysema with bronchiolitis obliterans after allogeneic peripheral blood stem cell transplantation (PBSCT) from an unrelated donor. The pathogenesis of air-leakage syndrome is not fully understood, and its management has not yet been established. This patient was treated with high-concentration oxygen, tube thoracostomy, percutaneous drainage with a pigtail catheter to relieve the tension pneumomediastinum, and mechanical ventilatory support. The patient has now recovered and is being followed on an outpatient basis.
Keywords: Air-leakage syndrome; Bronchiolitis obliterans; Peripheral blood stem cell transplantation
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