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The Korean Journal of Medicine 2008;74(4): 391-396.
원저 : 확대 대장 내시경에 따른 선구 형태와 Cyclooxygenase-2의 발현율
정준원, 장혜숙, 명승재, 김태훈, 이영미, 변정식, 양석균, 김진호
Correlation of pit pattern by magnifying colonoscopy with histologic features and COX-2 expression in colonic polyps
Jun-Won Chung, Hye-Sook Chang, Seung-Jae Myung, Tae Hun Kim, Young Mi Lee, Jeong-Sik Byeon, Suk-Kyun Yang, Jin-Ho Kim
인제 의대 부산 백병원 호흡기 내과
ABSTRACT
Background/Aims : Magnifying colonoscopy (MC) was introduced for prediction of pathologic findings. However, cyclooxgenase-2 (COX-2) expression in colonic polyps according to pit pattern has not been reported before. The aims of this study were to evaluate the usefulness of MC for differentiating polyps and to analyze COX-2 mRNA expression in colon polyps according to pit patterns. Methods : We studied 36 patients (M:F=26:10; median age 55 years) who received endoscopic polypectomy at Asan Medical Center. The pit patterns were classified into six types (type I, II, IIIL, IIIS, IV, and V). The expression of COX-2 mRNA was determined by reverse transcription-polymerase chain reaction. Results : Among 41 polyps from 36 patients, 38 polyps were diagnosed as benign colon polyps, and 3 polyps were diagnosed as early colon cancer. In assessing the histologic findings according to pit patterns, non-adenomatous polyps were detected in 50% of type I and II patterns, and pre-malignant polyps were detected in 94.5% of type IIIL, IIIS, IV, and V patterns. COX-2 mRNA expression rate increased in parallel with histologic grade (p=0.022). However, this was not correlated with pit pattern. Conclusions : MC pit patterns provide detailed gross morphologic features. COX-2 mRNA expression rate, while related to histologic progression, is not related directly to pit pattern, but further study is needed.
Keywords: Magnifying colonoscopy; Cyclooxygenase 2; Pit pattern
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