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The Korean Journal of Medicine 2008;74(3): 336-341.
증례 : 피부병변과 다발성 뇌경색을 동반한 특발성 호산구 증다증 1예
장선익 . 조일권 . 박상준 . 김정현 . 최승호 . 김선영 . 정성창, Il Kwan Cho, Sang Jun Park, Jung Hyun Kim, Sung Ho Choi, Sun Young Kim, Sung Chang Jung
Idiopathic hypereosinophilic syndrome associated with skin lesions and multiple brain infarctions
Sun Ik Jang, Il Kwan Cho, Sang Jun Park, Jung Hyun Kim, Sung Ho Choi, Sun Young Kim, Sung Chang Jung
경희대학교 의과대학 순환기내과학교실
ABSTRACT
Idiopathic hypereosinophilic syndrome (IHES) is a rare systemic disorder that’s characterized by peripheral eosinophilia and eosinophilic infiltration of multiple organs, including the heart, lungs, skin, liver, gastrointestinal tract and nervous system. IHES is associated with a broad range of clinical findings, depending on the involved organ and the severity of the infiltration. The diverse modes of clinical presentation occasionally lead to a false clinical diagnosis. There are no specific tests for diagnosing IHES, and the therapies remain controversial. In this report, we describe a 34-year-old man with IHES that was associated with multiple brain infarctions in both cerebral and cerebellar hemispheres. Five months earlier, the patient presented with erythematous scaly hyperkeratotic skin lesions on both legs. He was treated with anticoagulation therapy, aspirin and topical corticosteroid for about 1 month. All his symptoms and signs dramatically improved, except for the persistent peripheral eosinophilia. On follow-up after 8 months, the patient remained well without relapse or new lesions. (Korean J Med 74:336-341, 2008)
Keywords: Hypereosinophilic syndrome; Skin lesion; Cerebral infarction
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