| Comparison of the Naranjo and WHO-Uppsala Monitoring Centre criteria for causality assessment of adverse drug reactions |
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Myoung-Kyun Son, Yong-Won Lee, Han-Young Jung, Seung-Woo Yi, Kwang-Hoon Lee, Seung-Up Kim, Jae-Heon Jeong, Jae-Jun Park, Jung-Won Park, Chein-Soo Hong |
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고려대 안산병원 호흡기내과1, 고려대 안산병원 병리과2, 고려대 안산병원 흉부외과3 |
| 원저 : 약물유해반응의 인과관계 판정을 위한 Naranjo와 WHO-UMC 지표의 비교 |
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손명균 . 이용원, . 정한영 . 이승우 . 이광훈 김승업 . 정재헌 . 박재준 . 박중원, . 홍천수, Seung-Woo Yi, Kwang-Hoon Lee, Seung-Up Kim, Jae-Heon Jeong, Jae-Jun Park, Jung-Won Park, Chein-Soo Hong |
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| Abstract |
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Background/Aims : Several criteria have been proposed to increase the objectivity, reliability and validity of causality assessment of adverse drug reactions (ADR). We compared the Naranjo probability scale and the World Health Organization- Uppsala Monitoring Centre (WHO-UMC) causality categories to evaluate the validity and clinical usefulness of these criteria.
Methods : We evaluated 100 ADR cases with the Naranjo probability scale and the WHO-UMC causality categories. The Spearman rank coefficient was used to determine the correlation of these criteria. The evaluation of the ADR was categorized into four groups for the Naranjo system: definite, probable, possible, and doubtful, and six groups for the WHO‐UMC: certain, probable, possible, unlikely, conditional/unclassified, and unassessable.
Results : The criteria used form these two systems showed some differences when compared with the same ADR cases. The Spearman rank coefficient was 0.519 (p<0.001) and the agreement was 55% between the Naranjo probability scale and the WHO-UMC causality categories. The Naranjo probability scale includes measurements for drug concentration, objective evidence of ADR, ADR to previous exposures, responses to placebo, and the dose adjustment of drugs. However, few cases were evaluated for all of these measures.
Conclusions : The Naranjo probability scale may be helpful for assessing unexpected ADRs and useful for evaluators with little experience. However, some of the items are not utilized and there are discrepancies when compared with the WHO-UMC causality criteria.
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| Key Words:
Adverse drug reactions; Naranjo probability scale; World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causali |
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