| A case of henoch-Schönlein purpura complicated by hemorrhagic gastroenteritis and IgA nephropathy in a patient suffering with juvenile rheumatoid arthritis |
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Joonbeom Shin, Yeon-Ah Lee, Soo Young Moon, Doo-Hyun Woo |
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전남대학교병원 심장센터, 간호부, 전남대학교 심혈관계 특성화 사업단 |
| 증례 : 청소년 류마티스 관절염 환자에서 출혈성 위장관염으로 나타난 Henoch-Schönlein 자반증 1예 |
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신준범.이연아.문수영.우두현.이상훈.홍승재.양형인, Yeon-Ah Lee, Soo Young Moon, Doo-Hyun Woo |
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| Abstract |
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Henoch-Schönlein purpura (HSP) is a systemic vasculitis with IgA dominant immune complex deposits that affect the
small vessels in the skin, joints, gastrointestinal tract and kidneys. Gastrointestinal symptoms are common and the
manifestations include abdominal pain, bleeding, bowel infarction, intussusceptions or even perforation. Polyarticular onset
juvenile rheumatoid arthritis (JRA) is a rare form of arthritis that affects children and young adults. The relationship
between HSP and JRA is uncertain. We report on a 24-year-old man with a history of polyarticular onset JRA and HSP
that was complicated by hemorrhagic gastroenteritis. The gastroscopy and colonoscopic findings showed extensive
hemorrhagic inflammatory changes of the gastric and intestinal mucosa. The patient had severe bloody diarrheal
symptoms, abdominal pain and gross hematuria. The 24 hours urine chemistry profile showed the proteinuria was greater
than 4.5 g/day, and immunofluorescent staining of the renal biopsy specimen showed diffuse granular mesangial deposits
of IgA and C3. The abdominal manifestations and proteinuria were improved after methylprednisolone therapy.(Korean
J Med 73:453-456, 2007) |
| Key Words:
Henoch-Schönlein purpura, Polyarticular onset juvenile rheumatoid arthritis, Hemorrhagic gastritis, Hemorrhagic colitis, |
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