| Antiretroviral drug resistance among drug-naive HIV-1 infected patients |
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Seo Rin Kim, Eun Kyung Rheu, Young Mi Seol, Dong Heuck Cha, Su Jin Lee, Yeun Kyung Yoon, Soon Mi Park, Heyung Hoe Kim, Hak Sun Rheu, Soon Chul Ahn, Sun Hee Lee, Im Su Kwak, Goon Jae Cho |
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1Department of Cardiology, Catholic University of Daegu College of Medicine, Daegu, Korea |
| 원저 : 치료력이 없는 HIV 감염환자에서 약제내성 빈도 |
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김서린, Eun Kyung Rheu, Young Mi Seol, Dong Heuck Cha, Su Jin Lee, Yeun Kyung Yoon, Soon Mi Park, Heyung Hoe Kim, Hak Sun Rheu, Soon Chul Ahn, Sun Hee Lee, Im Su Kwak, Goon Jae Cho |
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| Abstract |
Background : The prevalence of HIV drug resistance mutations in drug-naive patients has been shown to differ with geographic origin. The purpose of this study is to assess the prevalence of transmitted antiretroviral drug resistance mutations in drug-naive patients in Korea.
Methods
: Genotypic resistance was determined by the use of the Viroseq Genotyping System in 42 antiretroviral treatment naive HIV-infected patients between March 2005 and July 2006. Transmitted drug resistance was estimated according to the IAS-USA 2005 definition, taking into account only major mutations in the protease and all mutations in the reverse transcriptase, including revertant mutations at codon 215.
Results
: The median age of the patients was 42 years and 37 (88%) were male. The median CD4+T cell count was 136/mm3 and the mean plasma RNA level was 4.98 log copies/mL. Among 42 patients studied, 37 (88%) were newly diagnosed patients. None of the patients were recent seroconverters; 38 patients (90%) were infected with subtype B and 4 patients were infected (10%) with the non-B subtype strains (2 patients with CRF01-AE 1 as CRF02-AG; 1 patient with subtype A). Of the 42 subjects tested, we found 2 (4.8%) mutations in NRTI (V118I), but did not find a mutation in NNRTI as well as in the PI region.
Conclusions
: The prevalence of transmitted antiretroviral drug resistance in drug-naive patients is still low in Korean patients.(Korean J Med 73:243-250, 2007)
Key Words : HIV, Antiretroviral agent, Drug resistance |
| Key Words:
HIV, Antiretroviral agent, Drug resistance |
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