| Effect of inhaled tiotropium on patients with COPD |
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Yang Il Kang, Tae Jun Noh, Hye Sook Choi, Cheon Woong Choi, Myung-Jae Park, Hong Mo Kang, Jee-Hong Yoo |
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경희대학교 의과대학 순환기내과학교실 |
| 원저 : 만성 폐쇄성 폐질환 환자에서 tiotropium 흡입제의 효과 |
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강양일, 노태준, 최혜숙, 최천웅, 박명재, 강홍모, 유지홍 |
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| Abstract |
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Background : Tiotropium is a long acting anticholinergic bronchodilator and it reduces exacerbations and improves the quality of life of patients with stable chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of tiotropium on dyspnea, the quality of life and the pulmonary function in patients with COPD.
Methods : Between April 2005 and April 2006, the patients with moderate to severe COPD, as based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and who needed to use long-acting bronchodilator were enrolled in this study. They inhaled tiotropium as a dry powder capsule, 18 μg once daily for six months, with using the HandihalerⓇ device. The lung function tests, including lung volume, the St. George's respiratory questionnaire and the MRC dyspnea scale, was measured at baseline and after 6 months treatment with tiotropium.
Results : 21 patients with COPD were enrolled. The mean age of the patients was 69 years and the mean baseline FEV1 was 1.0 L (40% predicted). Compared with the baseline, tiotropium produced significant improvement of the FEV1 (1.0±0.2 L vs. 1.1±0.3 L, respectively, p=0.013), IC (1.65±0.3 L vs. 1.7±0.3 L, respectively, p=0.037), the RV (4.0±0.7 L vs. 3.8±0.4, respectively, p=0.003), the SGRQ score (48.7±10 vs. 41.3±10.4, respectively, p<0.001), and the MRC dyspnea scale (3.4±0.6 vs. 3.0±0.8, respectively, p=0.009) after 6 months treatment. The dyspnea scale was associated with
physical activity, the impact on life, the inspiratory capacity and the residual volume rather than the symptom score or FEV1. The treatment was well tolerated.
Conclusions : Treatment with tiotropium once daily for 6 months improved lung functions, the health related quality of life and dyspnea.(Korean J Med 73:159-168, 2007) |
| Key Words:
Chronic obstructive pulmonary disease, Tiotropium, St George's respiratory questionnaire, MRC dyspnea scale, Lung funct |
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