Therapeutic effects of a long-acting formulation of lanreotide in Korean patients with acromegaly

Sae Jeong Yang,; Young Jin Seo,; Chai Ryoung Eun,; Hye Soo Chung,; Hye Jung Choi,; Nam Hoon Kim,; Hye Sook Kim,; Ju Ri Park,; Dong Jin Kim,; Hye Jin Yoo,; Soo Yeon Park,; Yun Jeong Lee,; Ohk Hyun,

Korean J Med > Volume 73(1); 2007 > Article

Original Article

The Korean Journal of Medicine 2007;73(1):50-57.

Therapeutic effects of a long-acting formulation of lanreotide in Korean patients with acromegaly

Sae Jeong Yang, Young Jin Seo, Chai Ryoung Eun, Hye Soo Chung, Hye Jung Choi, Nam Hoon Kim, Hye Sook Kim, Ju Ri Park, Dong Jin Kim, Hye Jin Yoo, Soo Yeon Park, Yun Jeong Lee, Ohk Hyun, , , , , ,

중앙대학교 의과대학 내과학교실

원저 : 한국인 말단 비대증에서 long acting lanreotide의 치료

양세정, 서영진, 은채령, 정혜수, 최혜정, 김남훈, 김혜숙, 박주리, 김동진, 류혜진, 박수연, 이윤정, 류옥현, 김희영, 이계원, 서지아, 김신곤, 최동섭, 백세현

Department of Internal Medicine, College of Medicine Chungang University, Seoul, Korea

Abstract

Background : The present study was conducted to examine the effects of a long-acting formulation of lanreotide (Somatulin-AutogelⓇ) in Korean acromegalic patients who had undergone surgery. Methods : The subjects in the study were 11 acromegalic patients (5 men and 6 women) who had undergone transsphenoidal tumor resection at Korea University Guro Hospital. The anthropometric parameters, blood pressure, fasting blood glucose (FBG), IGF-1, HbA1C, mass size and GH level following a 75 gm oral glucose tolerance test (OGTT) were measured in each subject before and after treatment with a long-acting formulation of lanreotide. Results : The median age of the subjects was 41 yrs (range: 28-52 yrs) (Table 1). The mean pre-operative levels of serum IGF-1 in the 11 patients was 1185¡¾323.58 ng/mL, and post-operatively it was 862¡¾314.06 ng/mL. The mean serum IGF-1 concentration decreased from 862¡¾314.06 ng/mL to 549¡¾371.62 ng/mL after 6 months treatment with the long-acting formulation of lanreotide (p=0.003, vs baseline, n=11), and it decreased further to 439¡¾342.53 ng/mL after 12 months treatment (p=0.005 vs baseline, n=10) (Table 3). Two patients achieved the target level of IGF-1. The HbA1C measured before and after lanreotide treatment was 5.8¡¾0.5% and 5.9¡¾0.3%, respectively. Conclusions : This study showed that a long-acting formulation of lanreotide decreased the IGF-1 and GH levels without significant side effects. In spite of the small number of subjects in this study, these findings suggest that this formulation of lanreotide is effective for the post-operative management of acromegaly.(Korean J Med 73:50-57, 2007)