| The relation of the testosterone level with metabolic syndrome and coronary artery disease in Korean middle-aged and elderly men |
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Ho Han, Jin Ho Shin, Chang Beom Lee, Yong Soo Park, Dong Sun Kim, You Hern Ahn, Tae Wha Kim, Woong Hwan Choi |
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성균관대학교 의과대학 삼성서울병원 내과학교실, 제주대학교 의과대학 내과학교실2 |
| 원저 : 한국 남성에서 테스토스테론 농도와 대사 증후군 및 관상동맥 질환과의 연관성 |
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한 호, 신진호, 이창범, 박용수, 김동선, 안유헌, 김태화, 최웅환 |
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Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Internal Medicine, Cheju National University School of Medicine, Cheju, Korea2 |
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| Abstract |
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Background : Abdominal obesity is an essential component of metabolic syndrome and it causes insulin resistance.
In contrast to women, the serum testosterone level has an inverse relationship with the visceral fat mass in men.
Therefore, we investigated the relation of the serum testosterone concentration with metabolic syndrome and coronary
artery disease in Korean middle-aged and elderly men.
Methods : 211 male subjects who were admitted to the cardiology department due to chest pain at Hanyang
University Hospital from January to December, 2005 (mean age: 59.1¡¾10.7 yrs) were enrolled in this study. All the blood
samplings for laboratory tests, including the testosterone and estradiol tests, were done between 6 AM to 8 AM.
Coronary artery disease was defined when there was more than 50% narrowing of the vascular lumen on the coronary
angiography. Metabolic syndrome was defined according to the NCEP-ATP III guidelines.
Results : Among the other cardiovascular risk factors, metabolic syndrome was the most important contributor to
coronary artery disease (adjusted OR=4.32, 95% CI: 1.96-9.52). Even after adjustment for age, BMI, smoking, alcohol
consumption and hypertension, lower testosterone was associated with a higher fasting glucose level (p<0.01) and higher
insulin resistance (p<0.05). Each SD (1.88 ng/mL) increase in the total testosterone was associated with a 51% reduced
risk of having metabolic syndrome (OR=0.49; 95% CI, 0.36-0.68). Although men with coronary artery disease tended to
have lower testosterone levels, there was no statistical significance.
Conclusions : Lower testosterone levels might have a causative role in the development of metabolic syndrome and
possibly coronary artery disease through the induction of insulin resistance.(Korean J Med 73:34-43, 2007)
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| Key Words:
Testosterone, Metabolic syndrome, Insulin resistance, Coronary artery disease |
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