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The Korean Journal of Medicine 2007;72(2): 214-220.
利앸 : 룓 꽭룷떊寃쎈궡遺꾨퉬븫醫낆쓣 룞諛섑븳 젣1삎 떎諛쒖꽦 궡遺꾨퉬꽑醫낆쬆 1삁
떖쑄닔
A case of multiple endocrine neoplasia type 1 with pulmonary large cell neuroendocrine carcinoma
Yun Su Sim
怨좊젮븰援 쓽怨쇰븰 궡怨쇳븰援먯떎
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ABSTRACT
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal- ominant inherited syndrome that's characterized by the combined occurrence of tumors of the parathyroid glands, endocrine pancreas and anterior pituitary gland. Pulmonary large cell neuroendocrine carcinoma and colon leiomyoma in patients with MEN 1 are rare findings. Here we report a 51-year-old man who was admitted because of a solitary pulmonary nodule that was seen on the whole body MRI. The laboratory results showed hypercalcemia and hypophosphatemia, and the hormonal studies revealed an elevated level of intact parathyroid hormone (iPTH). The 99mTc-sestamibi scintigraphy showed three hot-uptake lesions in the lower neck, and colonoscopy revealed two polyps. Right middle lobe lobectomy was performed and pulmonary large cell neuroendocrine carcinoma was comfirmed. Both parathyroidectomy and colonscopic polypectomy were performed and parathyroid hyperplasia and colon leiomyoma were confirmed. This is the first case report of pulmonary large cell neuroendocrine carcinoma associated with MEN 1 in Korean.(Korean J Med 72:S214-S220, 2007) Key Words : Multiple endocrine neoplasia type 1, Lung large cell neuroendocrine carcinoma, Leiomyoma
Keywords: Multiple endocrine neoplasia type 1, Lung large cell neuroendocrine carcinoma, Leiomyoma
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