| In vitro antimicrobial activity of cefditoren against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates |
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Yee Gyung Kwak, Eun Ju Choo, Su Jin Park, Jeong Eun Lee, Jin Yong Jeong, Sang Ho Choi, Nam Joong Kim, Yang Soo Kim, Jun Hee Woo, Jiso Ryu |
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고려대학교 의과대학 내과학교실 |
| 원저: Streptococcus pneumoniae와 Haemophilus influenzae 임상분리주에 대한 Cefditoren의 시험관내 항균력 |
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곽이경, Eun Ju Choo, Su Jin Park, Jeong Eun Lee, Jin Yong Jeong, Sang Ho Choi, Nam Joong Kim, Yang Soo Kim, Jun Hee Woo, Jiso Ryu |
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| Abstract |
Background : The aim of this study was to determine the in vitro activity of cefditoren, an oral third-generation aminothiazolyl cephalosporin, against Streptococcus pneumoniae and Haemophilus
influenzae clinical isolates in a tertiary hospital.
Methods
: We have studied the in vitro activities of cefditoren and other oral antibiotics against 120 S. pneumoniae isolates, including 80 penicillin non-susceptible isolates and 80 H. influenzae
isolates from clinical specimens of patients at the Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by the agar dilution method.
Results
: All S. pneumoniae strains tested were inhibited by 1 g/mL of cefditoren (MIC50/MIC90 0.25/1 μg/mL; range 0.015～1 μg/mL). The MICs were lower for penicillin-susceptible S. pneumoniae
(MIC90 0.015 g/mL) as compared to penicillin-intermediate resistant (MIC90 0.5 g/mL) or penicillinresistant strains (MIC90 1 μg/mL). Cefditoren was active against all tested H. influenzae strains
(MIC50/MIC90 0.015/0.03 μg/mL; range <0.008～0.03 g/mL) and its activity was comparable to levofloxacin and cefixime.
Conclusions
: Cefditoren had an excellent activity against S. pneumoniae and H. influenzae irrespective of penicillin or ampicillin resistance, respectively. The results of this study suggest that
cefditoren is a good choice of an antibiotic to use for empirical oral treatment of community-acquired respiratory tract infections.(Korean J Med 72:68-73, 2007)
Key Words : Cefditoren, Streptococcus pneumoniae, Haemophilus influenzae |
| Key Words:
Cefditoren, Streptococcus pneumoniae, Haemophilus influenzae |
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