| Home | E-Submission | Sitemap | Contact Us |  
logo
The Korean Journal of Medicine 2007;72(1): 68-73.
원저: Streptococcus pneumoniae와 Haemophilus influenzae 임상분리주에 대한 Cefditoren의 시험관내 항균력
곽이경, Eun Ju Choo, Su Jin Park, Jeong Eun Lee, Jin Yong Jeong, Sang Ho Choi, Nam Joong Kim, Yang Soo Kim, Jun Hee Woo, Jiso Ryu
In vitro antimicrobial activity of cefditoren against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates
Yee Gyung Kwak, Eun Ju Choo, Su Jin Park, Jeong Eun Lee, Jin Yong Jeong, Sang Ho Choi, Nam Joong Kim, Yang Soo Kim, Jun Hee Woo, Jiso Ryu
고려대학교 의과대학 내과학교실
ABSTRACT
Background : The aim of this study was to determine the in vitro activity of cefditoren, an oral third-generation aminothiazolyl cephalosporin, against Streptococcus pneumoniae and Haemophilus influenzae clinical isolates in a tertiary hospital. Methods : We have studied the in vitro activities of cefditoren and other oral antibiotics against 120 S. pneumoniae isolates, including 80 penicillin non-susceptible isolates and 80 H. influenzae isolates from clinical specimens of patients at the Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by the agar dilution method. Results : All S. pneumoniae strains tested were inhibited by 1 g/mL of cefditoren (MIC50/MIC90 0.25/1 μg/mL; range 0.015~1 μg/mL). The MICs were lower for penicillin-susceptible S. pneumoniae (MIC90 0.015 g/mL) as compared to penicillin-intermediate resistant (MIC90 0.5 g/mL) or penicillinresistant strains (MIC90 1 μg/mL). Cefditoren was active against all tested H. influenzae strains (MIC50/MIC90 0.015/0.03 μg/mL; range <0.008~0.03 g/mL) and its activity was comparable to levofloxacin and cefixime. Conclusions : Cefditoren had an excellent activity against S. pneumoniae and H. influenzae irrespective of penicillin or ampicillin resistance, respectively. The results of this study suggest that cefditoren is a good choice of an antibiotic to use for empirical oral treatment of community-acquired respiratory tract infections.(Korean J Med 72:68-73, 2007) Key Words : Cefditoren, Streptococcus pneumoniae, Haemophilus influenzae
Keywords: Cefditoren, Streptococcus pneumoniae, Haemophilus influenzae
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplementary Material  Supplementary Material
  E-Mail
Share:      
METRICS
930
View
2
Download
Editorial Office
101-2501, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-2271-6791   Fax: +82-2-790-0993    E-mail: kaim@kams.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Association of Internal Medicine. All rights reserved.                powerd by m2community