| Clinical characteristics of elderly Korean patients with peptic ulcer |
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Ki Dong Yu, Nayoung Kim, Young Soo Park, Jin Hyeok Hwang, Jin Wook Kim, Dong Ho Lee, Sook Hyang Jeong, Kwang Hyuck Lee, Hyung Suk Lee, Kyung Keun Kwack, Kwang Il Kim, Cheol Ho Kim |
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고려대학교 의과대학 내과학교실 |
| 원저:한국 노인 환자에서 소화성궤양의 임상적 특징 |
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유기동, Nayoung Kim, Young Soo Park, Jin Hyeok Hwang, Jin Wook Kim, Dong Ho Lee, Sook Hyang Jeong, Kwang Hyuck Lee, Hyung Suk Lee, Kyung Keun Kwack, Kwang Il Kim, Cheol Ho Kim |
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| Abstract |
Background : The incidence of peptic ulcer has decreased in the general population, but it has
increased for the geriatric patients worldwide. The aim of the study is to determine the age-related
characteristics of peptic ulcer patients.
Methods
: A total of 277 patients (195 men and 82 women), who were diagnosed with peptic ulcer
from May 2003 to Dec 2004, were analyzed retrospectively. The clinical characteristics of peptic ulcer
were compared between the two groups, that is, 138 elderly (= 65 yrs) and 139 non-elderly (= 50 yrs)
patients.
Results
: Peptic ulcer in the elderly were located more atypically (high body and the greater
curvature side of the mid and low body), the lesions were large and healed slowly. In the elderly
group, 50.7% of the ulcers were gastric and 36.2% were duodenal. On the other hand, in the
non-elderly group, 30.2% and 57.6% of the ulcers were gastric and duodenal, respectively. There
was no difference of the main symptoms between the two groups. For endoscopically bleeding ulcer,
the use of NSAID was statistically significant (p=0.006) only for the elderly group. The presence of
Helicobacter pylori was less common in the elderly group than in the non-elderly (57.7% vs 77%,
respectively, p=0.001). In the case of gastric ulcer, the rate of H. pylori infection was similar between
the two groups (62.9% vs 73.8%, respectively, p=0.233). In contrast, in the case of duodenal ulcer,
H. pylori infection was less common for the elderly patients than in the non-elderly patients (51%
vs 77.5%, respectively, p=0.002).
Conclusions
: For the elderly patients with peptic ulcer in Korea, the role of H. pylori was
relatively less important that it was for the non-eldery group. On the contrary, NSAID, aspirin and
combined chronic illness seem to contribute to ulcer. Bleeding peptic ulcer was discovered in both groups with no significant difference in the occurrence rate.(Korean J Med 71:501-510,
2006)
Key Words : Peptic ulcer, Helicobacter pylori |
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