Korean J Med > Volume 71(4); 2006 > Article
The Korean Journal of Medicine 2006;71(4):442-448.
Treatment with anti-cancer chemotherapy in a patient with fever of unknown origin and progressive pulmonary nodules
Yu Jung Kim, Sunyoung Kim, Myoung Don Oh, Chul Gyu Yoo, Dae Seog Heo, Chul Woo Kim, Yung Jue Bang
고려대학교 의과대학 내과학교실
증례:수년에 걸쳐 진행한 폐결절을 가진 불명열 환자에서의 항암화학요법 1예
김유정, Sunyoung Kim, Myoung Don Oh, Chul Gyu Yoo, Dae Seog Heo, Chul Woo Kim, Yung Jue Bang
Abstract
Classic causes of fever of unknown origin (FUO) are infections, neoplasms, collagen vascular diseases and drugs. However, large studies of FUO have consistently reported that a considerable proportion of patients with FUO remain undiagnosed. We report a patient with a prolonged course of FUO and progressive pulmonary nodules in whom extensive clinical and laboratory evaluation did not reveal specific diagnosis. The patient had recurrent episodes of fever for more than three years, and the pulmonary nodules gradually progressed in size and number despite administration of antibiotics including antifungal and antituberculosis agents. Several pathologic examinations demonstrated an organizing pneumonia or non-neoplastic lung parenchyma with lymphoplasmacytic infiltration only. After a protracted course of disease, we thought that this patient might have lymphoproliferative disorder, possibly EBV-associated, and started anti-cancer chemotherapy. He was successfully treated with eight cycles of chemotherapy including cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP).(Korean J Med 71:442-448, 2006) Key Words : Fever of unknown origin, Chemotherapy, Lymphoproliferative disorder


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