| Carotid artery remodeling in patients with acute coronary syndrome and chronic stable angina |
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Jeong Rang Park, Tae Jung Kwon, Young Ran Kang, So Ra Park, Jin Sin Kho, Sung Il Im, Sung Ji Park, Chung Hwan Kwak, Jin Yong Hwang |
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고려대학교 의과대학 내과학교실 |
| 원저:안정형 협심증과 급성 관상동맥 증후군 환자에서 경동맥의 재형성 |
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박정랑, Tae Jung Kwon, Young Ran Kang, So Ra Park, Jin Sin Kho, Sung Il Im, Sung Ji Park, Chung Hwan Kwak, Jin Yong Hwang |
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| Abstract |
Background : Acute adaptive vascular remodeling occurs in active and unstable inflammatory
plaques. It has been suggested that the adaptive coronary vascular remodeling, in patients with acute
coronary syndrome (ACS), may be systemic and may show similar vascular remodeling in the
carotid arteries. We investigated the ultrasonographic features of the common carotid artery (CCA)
to determine whether the arterial expansive remodeling found in the coronary artery occurs in the
carotid arteries of patients with ACS.
Methods
: We measured lumen diameter (LD), interadventitial diameter (IAD) and intima media
thickness (IMT) using a B-mode ultrasound in both common carotid arteries in patients with ACS
(N=74) and chronic stable angina (CSA) (N=31). Positive remodeling was arbitrarily defined as an
IMTmax >1 mm and IAD >8 mm and negative remodeling as an IMTmax >1 mm and IAD <7 mm.
Other values were defined as “no remodeling”
Results
: There were no significant differences in LD IAD and maximal IMT of the right CCA
and the left CCA in comparisons between the ACS and the CSA patient groups. There were no
differences for number of cases with no remodeling or differences in positive and negative remodeling
in the right common carotid artery and left common carotid artery in comparisons between the ACS
and CSA patient groups. . Presence of plaque in both common carotid arteries showed similar
frequency in the ACS and CSA patient groups. The characteristics of carotid artery plaques were not
different in the two groups. The remodeling index (IAD/LD) was correlated with IMTmax (right
CCA r=0.797, p<0.001; left CCA r=0.860, p<0.001).
Conclusions
: The common carotid arterial structure of ACS patients was not different from that
of CSA patients. Therefore, these results suggest that the expansive arterial remodeling, due to coronary inflammatory plaques, appears to take place locally rather than systemically.(Korean J Med
71:266-275, 2006)
Key Words : Acute coronary syndrome, Arterial remodeling, Carotid artery |
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