| The effect of Helicobacter pylori eradication on the improvement of the symptoms in patients with functional dyspepsia and peptic ulcer disease |
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Eun Jae Lee, Chang Woo Gham, Tae Woon Park, Sung Il Hong, Geun Jun Ko, Chang Hwan Choi, Ki Joon Han, Hyeon Geun Cho, Jae Eun Lee, Jae Young Kim |
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Seoul National University College of Medicine |
| 헬리코박터 제균 요법이 기능성 소화불량증 환자와 소화성 궤양 환자의 증상 호전에 미치는 효과 |
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이은재, Chang Woo Gham, Tae Woon Park, Sung Il Hong, Geun Jun Ko, Chang Hwan Choi, Ki Joon Han, Hyeon Geun Cho, Jae Eun Lee, Jae Young Kim |
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| Abstract |
Background : In the functional dyspepsia, Helicobacter pylori has been suggested as a causative agent. But, the effect of H. pylori eradication is still debated on functional dyspesia. The purpose of this study was to evaluate the effectiveness of the H. pylori eradication therapy in the improvement of the symptoms in patients with functional dyspepsia.
Methods
: The convenience sample consisted of 123 patients with functional dyspepsia and 80 patients with peptic ulcer diseases who were infected with H. pylori. All patients had received eradication therapy of H. pylori for one or two weeks and additional therapy with H2RA or PPI for one to five weeks. After the treatment was completed, the patients were asked about their symptomatic improvement every three months. The degree of symptom was rated on a five-point Likert scale.
Results
: Overall eradication rate of H. pylori was 82.8% (168/203), and there were no significant differences in the eradication rate between the two groups and between one-week and two-week eradication therapies. The mean follow-up period was 12 months. The symptomatic improvement in both group was maintained over 12 months in most patients (PUD 72.5% vs. FD 67.4%). In addition, the symptomatic improvement in the patients with eradication success was maintained significantly
longer than those with eradication failure in both group (FD p=0.007 vs. PUD p=0.014).
Conclusions
: The eradication therapy of H. pylori can be one of the therapeutic options for patients with functional dyspepsia and that eradication failure may cause the recurrence of the symptom.
Key Words : Functional Dyspepsia, Helicobacter pylori, Peptic Ulcer Diseases |
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